User: Guest  Login
Document type:
journal article 
Author(s):
Da Costa, CU; Wantia, N; Kirschning, CJ; Busch, DH; Rodriguez, N; Wagner, H; Miethke, T 
Title:
Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. 
Abstract:
Heat shock protein 60 (HSP60) from Chlamydia pneumoniae was described to trigger in vitro inflammatory and cytokine responses including TNF and IL-12p40. Although it can be found in atherosclerotic plaques of patients, the stimulatory potential of chlamydial and other HSP60 in vivo is unclear. We now report that chlamydial HSP60 fails to induce TNF expression in vivo, and significant serum levels of IL-12p40 are only found upon intraperitoneal injection of high doses of HSP60 or after intravenou...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2004 
Journal volume:
34 
Journal issue:
10 
Pages contribution:
2874-84 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene