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Dokumenttyp:
journal article 
Autor(en):
Meier, A; Kirschning, CJ; Nikolaus, T; Wagner, H; Heesemann, J; Ebel, F 
Titel:
Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. 
Abstract:
Aspergillus fumigatius is a ubiquitous saprophytic fungus that has become the most prevalent airborne fungal pathogen for immunocompromised patients during the last two decades. In this report we have analysed how macrophages recognize this microorganism. Using transfected human HEK 293 cells we demonstrate that NF-kappaB-dependent promoter activation triggered by A. fumigatus is mediated by Toll-like receptors TLR2 and TLR4, whereas no activation was observed in cells overexpressing other disti...    »
 
Zeitschriftentitel:
Cell Microbiol 
Jahr:
2003 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
561-70 
Sprache:
eng 
Print-ISSN:
1462-5814 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene