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- Document type:
- Journal Article
- Author(s):
- Lembo, A; Kalis, C; Kirschning, CJ; Mitolo, V; Jirillo, E; Wagner, H; Galanos, C; Freudenberg, MA
- Title:
- Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice.
- Abstract:
- The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus aureus.
- Journal title abbreviation:
- Infect Immun
- Year:
- 2003
- Journal volume:
- 71
- Journal issue:
- 10
- Pages contribution:
- 6058-62
- Language:
- eng
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/14500530
- Print-ISSN:
- 0019-9567
- TUM Institution:
- Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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