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Dokumenttyp:
Journal Article
Autor(en):
Spies, B; Hochrein, H; Vabulas, M; Huster, K; Busch, DH; Schmitz, F; Heit, A; Wagner, H
Titel:
Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice.
Abstract:
We analyzed whether the immunobiology of vaccinating plasmid DNA containing a transcription unit for OVA is influenced by immunostimulatory CpG motifs in the plasmid backbone. Indeed, plasmid DNA differentially activated in vitro myeloid and plasmacytoid dendritic cells (DCs) provided they expressed the CpG-DNA receptor, Toll-like receptor 9 (TLR9). Dependent on the DC subset, activation resulted in type 1 IFN production, while both DC subsets produced IL-6 and up-regulated expression of costimu...     »
Zeitschriftentitel:
J Immunol
Jahr:
2003
Band / Volume:
171
Heft / Issue:
11
Seitenangaben Beitrag:
5908-12
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14634101
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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