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Dokumenttyp:
journal article 
Autor(en):
Spies, B; Hochrein, H; Vabulas, M; Huster, K; Busch, DH; Schmitz, F; Heit, A; Wagner, H 
Titel:
Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. 
Abstract:
We analyzed whether the immunobiology of vaccinating plasmid DNA containing a transcription unit for OVA is influenced by immunostimulatory CpG motifs in the plasmid backbone. Indeed, plasmid DNA differentially activated in vitro myeloid and plasmacytoid dendritic cells (DCs) provided they expressed the CpG-DNA receptor, Toll-like receptor 9 (TLR9). Dependent on the DC subset, activation resulted in type 1 IFN production, while both DC subsets produced IL-6 and up-regulated expression of costimu...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2003 
Band / Volume:
171 
Heft / Issue:
11 
Seitenangaben Beitrag:
5908-12 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene