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Document type:
journal article 
Author(s):
Prebeck, S; Brade, H; Kirschning, CJ; da Costa, CP; Dürr, S; Wagner, H; Miethke, T 
Title:
The Gram-negative bacterium Chlamydia trachomatis L2 stimulates tumor necrosis factor secretion by innate immune cells independently of its endotoxin. 
Abstract:
The endotoxin of Chlamydia trachomatis L(2), the causative agent of lymphogranuloma venerum, has been described as an endotoxin with an atypical structure and weak stimulatory activity. It is, however, unclear whether chlamydial endotoxin plays a role in the stimulation of innate immune cells upon contact with the whole microorganism C. trachomatis L(2). We show here that chlamydial endotoxin and, as expected, Escherichia coli O55:B5 endotoxin depend on Toll-like receptor 4 without depending on...    »
 
Journal title abbreviation:
Microbes Infect 
Year:
2003 
Journal volume:
Journal issue:
Pages contribution:
463-70 
Language:
eng 
Print-ISSN:
1286-4579 
TUM Institution:
Institut für Virologie ; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene