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Document type:
journal article 
Author(s):
Hauptmann, H; Metzger, J; Schnitzbauer, A; Cuilleron, CY; Mappus, E; Luppa, PB 
Title:
Syntheses and ligand-binding studies of 1 alpha- and 17 alpha-aminoalkyl dihydrotestosterone derivatives to human sex hormone-binding globulin. 
Abstract:
We report on the syntheses of 1 alpha- and 17 alpha-aminoalkyl dihydrotestosterone (DHT) derivatives and the particularly high binding affinity of the 1 alpha-aminohexyl ligand for human sex hormone-binding globulin (SHBG). The two 17 alpha-aminopropyl-17 beta-hydroxy-5 alpha-androstan-3-one (1) and 17 alpha-aminocaproylamidoethyl-17 beta-hydroxy-5 alpha-androstan-3-one (2) derivatives were synthesized via a 17beta-spirooxirane intermediate in high yields. The 1 alpha-aminohexyl-17 beta-hydroxy-...    »
 
Journal title abbreviation:
Steroids 
Year:
2003 
Journal volume:
68 
Journal issue:
7-8 
Pages contribution:
629-39 
Language:
eng 
Print-ISSN:
0039-128X 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie