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Dokumenttyp:
journal article 
Autor(en):
Yang, S; Wang, X; Contino, G; Liesa, M; Sahin, E; Ying, H; Bause, A; Li, Y; Stommel, JM; Dell'antonio, G; Mautner, J; Tonon, G; Haigis, M; Shirihai, OS; Doglioni, C; Bardeesy, N; Kimmelman, AC 
Titel:
Pancreatic cancers require autophagy for tumor growth. 
Abstract:
Macroautophagy (autophagy) is a regulated catabolic pathway to degrade cellular organelles and macromolecules. The role of autophagy in cancer is complex and may differ depending on tumor type or context. Here we show that pancreatic cancers have a distinct dependence on autophagy. Pancreatic cancer primary tumors and cell lines show elevated autophagy under basal conditions. Genetic or pharmacologic inhibition of autophagy leads to increased reactive oxygen species, elevated DNA damage, and a m...    »
 
Zeitschriftentitel:
Genes Dev 
Jahr:
2011 
Band / Volume:
25 
Heft / Issue:
Seitenangaben Beitrag:
717-29 
Sprache:
eng 
Print-ISSN:
0890-9369 
TUM Einrichtung:
Kinderklinik und Poliklinik