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Document type:
journal article 
Author(s):
Djafarzadeh, R; Noessner, E; Engelmann, H; Schendel, DJ; Notohamiprodjo, M; von Luettichau, I; Nelson, PJ 
Title:
GPI-anchored TIMP-1 treatment renders renal cell carcinoma sensitive to FAS-meditated killing. 
Abstract:
The resistance of tumours to immune-mediated lysis has been linked to the biology of matrix metalloproteinases (MMPs), and specifically to the cell surface expression of MMPs by the tumour cell. The endogenous tissue inhibitors of metalloproteinases (TIMPs) exhibit diverse physiological/biological functions including the moderation of tumour growth, metastasis and apoptosis. These biologic activities are mediated in part by the stoichiometry of TIMP/MMP/cell surface protein interactions. A glyco...    »
 
Journal title abbreviation:
Oncogene 
Year:
2006 
Journal volume:
25 
Journal issue:
10 
Pages contribution:
1496-508 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
Kinderklinik und Poliklinik