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Document type:
journal article 
Author(s):
Schaadt, E; Baier, B; Mautner, J; Bornkamm, GW; Adler, B 
Title:
Epstein-Barr virus latent membrane protein 2A mimics B-cell receptor-dependent virus reactivation. 
Abstract:
Latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV) shares protein motifs with the B-cell receptor that play a role in B-cell receptor signalling and has been shown to mimic an activated B-cell receptor by providing a survival signal for mature B cells in transgenic mice. Conversely, LMP2A has been reported not to support but to inhibit B-cell receptor signalling with respect to virus reactivation and to block lytic virus induction after anti-Ig treatment of EBV-infected B cells. To s...    »
 
Journal title abbreviation:
J Gen Virol 
Year:
2005 
Journal volume:
86 
Journal issue:
Pt 3 
Pages contribution:
551-9 
Language:
eng 
Print-ISSN:
0022-1317 
TUM Institution:
Kinderklinik und Poliklinik