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Dokumenttyp:
journal article 
Autor(en):
Kruetzmann, S; Rosado, MM; Weber, H; Germing, U; Tournilhac, O; Peter, HH; Berner, R; Peters, A; Boehm, T; Plebani, A; Quinti, I; Carsetti, R 
Titel:
Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. 
Abstract:
Splenectomized and asplenic patients have a high incidence of infections by encapsulated bacteria and do not respond to polysaccharide vaccines. To understand whether the absence of the spleen is associated with a defined B cell defect, we analyzed B cell subsets in the peripheral blood. We found that a population of B cells known as immunoglobulin (Ig)M memory is lacking in patients without spleen. The absence of IgM memory B cells correlates with an impaired immune response to encapsulated bac...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2003 
Band / Volume:
197 
Heft / Issue:
Seitenangaben Beitrag:
939-45 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
Kinderklinik und Poliklinik