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Dokumenttyp:
journal article 
Autor(en):
Nimmerjahn, F; Milosevic, S; Behrends, U; Jaffee, EM; Pardoll, DM; Bornkamm, GW; Mautner, J 
Titel:
Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy. 
Abstract:
Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from the cytosolic protein neomycin phosphotransferase II (NeoR) on MHC class II is mediated by autophagy. This presentation pathway involves the sequestration of NeoR into autophagosomes...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2003 
Band / Volume:
33 
Heft / Issue:
Seitenangaben Beitrag:
1250-9 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
Kinderklinik und Poliklinik