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Dokumenttyp:
journal article 
Autor(en):
Staege, MS; Gorelov, V; Bulankin, A; Fischer, U; Dumon, K; Hohndorf, L; Hattenhorst, U; Kramm, C; Burdach, S 
Titel:
Stable transgenic expression of IL-2 and HSV1-tk by single and fusion tumor cell lines bearing EWS/FLI-1 chimeric genes. 
Abstract:
In augmenting systemic anti-tumor immune response, the authors evaluated the genetic modification of Ewing family tumor (EFT) cell lines for use as allogeneic vaccines. EFT cell lines A673 and RD-ES were transfected with cDNAs for human interleukin (IL)-2 and/or HSV1 thymidine kinase (HSV1-tk), respectively. Clones with high and stable secretion of IL-2 alone or with coexpression of functional HSV1-tk were obtained and their features were analyzed. IL-2 expressing clones derived from the A673 ce...    »
 
Zeitschriftentitel:
Pediatr Hematol Oncol 
Jahr:
2003 
Band / Volume:
20 
Heft / Issue:
Seitenangaben Beitrag:
119-40 
Sprache:
eng 
Print-ISSN:
0888-0018 
TUM Einrichtung:
Kinderklinik und Poliklinik