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Dokumenttyp:
journal article 
Autor(en):
Bel Aiba, RS; Dimova, EY; Görlach, A; Kietzmann, T 
Titel:
The role of hypoxia inducible factor-1 in cell metabolism--a possible target in cancer therapy. 
Abstract:
In many cancer types, intratumoural hypoxia is linked to increased expression and activity of the transcription factor hypoxia-inducible factor (HIF-1alpha), which is associated with poor patient prognosis. This increased the interest in HIF-1alpha as a cancer drug target. Further, HIF-1alpha has also a central role in the adaptive cellular programme responding to hypoxia in normal tissues. Many of the HIF-1alpha-regulated genes encode enzymes of metabolic pathways. Therefore, studying the link...    »
 
Zeitschriftentitel:
Expert Opin Ther Targets 
Jahr:
2006 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
583-99 
Sprache:
eng 
Print-ISSN:
1472-8222 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler