Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Djordjevic, T; Hess, J; Herkert, O; Görlach, A; BelAiba, RS 
Titel:
Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway. 
Abstract:
Pulmonary hypertension is associated with enhanced thrombogenicity of the vessel wall contributing to vascular remodeling. However, the signaling mechanisms promoting this prothrombotic state are not resolved. Here we investigated the role of the GTPase Rac in the regulation of tissue factor (TF) expression and activity in response to thrombin in pulmonary artery smooth muscle cells (PASMC). TF mRNA and protein expression and surface procoagulant activity were increased by thrombin in PASMC. The...    »
 
Zeitschriftentitel:
Antioxid Redox Signal 
Jahr:
2004 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
713-20 
Sprache:
eng 
Print-ISSN:
1523-0864 
TUM Einrichtung:
r Kinderkardiologie und angeborene Herzfehler