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Document type:
journal article 
Author(s):
Pape, M; Engelhard, K; Eberspächer, E; Hollweck, R; Kellermann, K; Zintner, S; Hutzler, P; Werner, C 
Title:
The long-term effect of sevoflurane on neuronal cell damage and expression of apoptotic factors after cerebral ischemia and reperfusion in rats. 
Abstract:
We investigated the long-term effects of sevoflurane on histopathologic injury and key proteins of apoptosis in a rat hemispheric ischemia/reperfusion model. Sixty-four male Sprague-Dawley rats were randomly assigned to Group 1 (fentanyl and N2O/O2; control) and Group 2 (2.0 vol% sevoflurane and O2/air). Ischemia (45 min) was produced by unilateral common carotid artery occlusion plus hemorrhagic hypotension (mean arterial blood pressure 40 mm Hg). Animals were killed after 1, 3, 7, and 28 days...    »
 
Journal title abbreviation:
Anesth Analg 
Year:
2006 
Journal volume:
103 
Journal issue:
Pages contribution:
173-9, table of contents 
Language:
eng 
Print-ISSN:
0003-2999 
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie