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Dokumenttyp:
journal article 
Autor(en):
Kremer, M; Quintanilla-Martinez, L; Fuchs, M; Gamboa-Dominguez, A; Haye, S; Kalthoff, H; Rosivatz, E; Hermannstädter, C; Busch, R; Höfler, H; Luber, B 
Titel:
Influence of tumor-associated E-cadherin mutations on tumorigenicity and metastasis. 
Abstract:
In this study, we investigated whether tumor-associated E-cadherin mutations impair the tumor-suppressive function of the cell adhesion molecule and influence metastasis formation in a severe combined immunodeficiency mouse model. The investigated E-cadherin mutations were in frame deletions of exons 8 (del 8) or 9 (del 9) and a point mutation in exon 8 (p8). Transfected human MDA-MB-435S carcinoma cells stably expressing wild-type (wt) or mutant E-cadherin were injected into the mouse mammary f...    »
 
Zeitschriftentitel:
Carcinogenesis 
Jahr:
2003 
Band / Volume:
24 
Heft / Issue:
12 
Seitenangaben Beitrag:
1879-86 
Sprache:
eng 
Print-ISSN:
0143-3334 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie; r Medizinische Statistik und Epidemiologie