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Document type:
journal article 
Author(s):
Parmar, A; Marz, S; Rushton, S; Holzwarth, C; Lind, K; Kayser, S; Döhner, K; Peschel, C; Oostendorp, RA; Götze, KS 
Title:
Stromal niche cells protect early leukemic FLT3-ITD+ progenitor cells against first-generation FLT3 tyrosine kinase inhibitors. 
Abstract:
Targeting constitutively activated FMS-like tyrosine kinase 3 [(FLT3); FLT3-ITD] with tyrosine kinase inhibitor (TKI) in acute myeloid leukemia (AML) leads to clearance of blasts in the periphery but not in the bone marrow, suggesting a protective effect of the marrow niche on leukemic stem cells. In this study, we examined the effect of stromal niche cells on CD34(+) progenitors from patients with FLT3-ITD(+) or wild-type FLT3 (FLT3-WT) AML treated with the TKIs SU5614 or sorafenib. TKIs effec...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2011 
Journal volume:
71 
Journal issue:
13 
Pages contribution:
4696-706 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
III. Medizinische Klinik und Poliklinik