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Dokumenttyp:
journal article 
Autor(en):
Schlee, M; Roth, A; Hornung, V; Hagmann, CA; Wimmenauer, V; Barchet, W; Coch, C; Janke, M; Mihailovic, A; Wardle, G; Juranek, S; Kato, H; Kawai, T; Poeck, H; Fitzgerald, KA; Takeuchi, O; Akira, S; Tuschl, T; Latz, E; Ludwig, J; Hartmann, G 
Titel:
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. 
Abstract:
Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at the 5' end. The exact structure of RNA activating RIG-I remains controversial. Here, we established a chemical approach for 5' triphosphate oligoribonucleotide synthesis and found that synthetic single-stranded 5' triphosphate oligoribonucleotides were unable to bind and activate RIG-I. Conversely, the a...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2009 
Band / Volume:
31 
Heft / Issue:
Seitenangaben Beitrag:
25-34 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik