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Dokumenttyp:
journal article 
Autor(en):
Miething, C; Peschel, C; Duyster, J 
Titel:
Targeting the oncogenic tyrosine kinase NPM-ALK in lymphoma: the role of murine models in defining pathogenesis and treatment options. 
Abstract:
Oncogenic tyrosine kinases play a ever growing role in the pathogenesis of human malignancies. In human non-Hodgkin lymphomas, the NPM-ALK oncogene arising from the t(2; 5) chromosomal translocation represents the most important oncogenic tyrosine kinase identified so far. The ALK-kinase is constitutively activated by NPM-induced dimerization and signals through a multitude of growth promoting and antiapoptotic pathways. Murine models have made a significant impact on the elucidation of the mole...    »
 
Zeitschriftentitel:
Curr Drug Targets 
Jahr:
2006 
Band / Volume:
Heft / Issue:
10 
Seitenangaben Beitrag:
1329-34 
Sprache:
eng 
Print-ISSN:
1389-4501 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik