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Dokumenttyp:
journal article 
Autor(en):
Oostendorp, RA; Robin, C; Steinhoff, C; Marz, S; Bräuer, R; Nuber, UA; Dzierzak, EA; Peschel, C 
Titel:
Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures. 
Abstract:
We recently established that two midgestation-derived stromal clones--UG26-1B6, urogenital ridge-derived, and EL08-1D2, embryonic liver-derived--support the maintenance of murine adult bone marrow and human cord blood hematopoietic repopulating stem cells (HSCs). In this study, we investigate whether direct HSC-stroma contact is required for this stem cell maintenance. Adult bone marrow ckit+ Ly-6C- side population (K6-SP) cells and stromal cells were cocultured under contact or noncontact condi...    »
 
Zeitschriftentitel:
Stem Cells 
Jahr:
2005 
Band / Volume:
23 
Heft / Issue:
Seitenangaben Beitrag:
842-51 
Sprache:
eng 
Print-ISSN:
1066-5099 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik