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Document type:
journal article 
Author(s):
zum Bueschenfelde, COM; Unternaehrer, J; Mellman, I; Bottomly, K 
Title:
Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells 
Abstract:
T cell activation has long been associated with the partitioning of Ag receptors and associated molecules to lipid microdomains. We now show that dendritic cells (DCs) also accomplish the selective recruitment to lipid rafts of molecules critical for Ag presentation. Using mouse bone marrow-derived DCs, we demonstrate that MHC class II molecules become substantially localized to rafts upon DC maturation. Even more striking is the fact that CD86 is recruited to rafts upon T cell-DC interaction. R...    »
 
Journal title abbreviation:
J Immunol 
Year:
2004 
Journal volume:
173 
Journal issue:
10 
Pages contribution:
6119-6124 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
III. Medizinische Klinik und Poliklinik