Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
zum Bueschenfelde, COM; Unternaehrer, J; Mellman, I; Bottomly, K 
Titel:
Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells 
Abstract:
T cell activation has long been associated with the partitioning of Ag receptors and associated molecules to lipid microdomains. We now show that dendritic cells (DCs) also accomplish the selective recruitment to lipid rafts of molecules critical for Ag presentation. Using mouse bone marrow-derived DCs, we demonstrate that MHC class II molecules become substantially localized to rafts upon DC maturation. Even more striking is the fact that CD86 is recruited to rafts upon T cell-DC interaction. R...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2004 
Band / Volume:
173 
Heft / Issue:
10 
Seitenangaben Beitrag:
6119-6124 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik