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Document type:
journal article 
Author(s):
Dechow, TN; Pedranzini, L; Leitch, A; Leslie, K; Gerald, WL; Linkov, I; Bromberg, JF 
Title:
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C 
Abstract:
Persistently activated Stat3 is found in many different cancers, including approximate to60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results d...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2004 
Journal volume:
101 
Journal issue:
29 
Pages contribution:
10602-10607 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
III. Medizinische Klinik und Poliklinik