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Dokumenttyp:
journal article 
Autor(en):
Ringshausen, I; Dechow, T; Schneller, F; Weick, K; Oelsner, M; Peschel, C; Decker, T 
Titel:
Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells. 
Abstract:
In the present work we investigated the role and biological significance of mitogen activated protein kinases (MAPK) in B-cell chronic lymphocytic leukaemia (B-CLL). The MAPK p38 was constitutively activated in B-CLL, but not in normal peripheral B cells. In addition, we demonstrated that the upstream kinases of p38, MKK3/6 were also constitutively activated in B-CLL cells. Furthermore, we determined by EMSA that the p38 MAP kinase pathway was not linked to the constitutive high expression of NF...    »
 
Zeitschriftentitel:
Leukemia 
Jahr:
2004 
Band / Volume:
18 
Heft / Issue:
12 
Seitenangaben Beitrag:
1964-70 
Sprache:
eng 
Print-ISSN:
0887-6924 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik