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Dokumenttyp:
Journal Article
Autor(en):
Maclean, KH; Keller, UB; Rodriguez-Galindo, C; Nilsson, JA; Cleveland, JL
Titel:
c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL.
Abstract:
Alterations in MYC and p53 are hallmarks of cancer. p53 coordinates the response to gamma irradiation (gamma-IR) by either triggering apoptosis or cell cycle arrest. c-Myc activates the p53 apoptotic checkpoint, and thus tumors overexpressing MYC often harbor p53 mutations. Nonetheless, many of these cancers are responsive to therapy, suggesting that Myc may sensitize cells to gamma-IR independent of p53. In mouse embryo fibroblasts (MEFs) and in E micro -myc transgenic B cells in vivo, c-Myc ac...     »
Zeitschriftentitel:
Mol Cell Biol
Jahr:
2003
Band / Volume:
23
Heft / Issue:
20
Seitenangaben Beitrag:
7256-70
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14517295
Print-ISSN:
0270-7306
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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