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Dokumenttyp:
journal article 
Autor(en):
Maclean, KH; Keller, UB; Rodriguez-Galindo, C; Nilsson, JA; Cleveland, JL 
Titel:
c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. 
Abstract:
Alterations in MYC and p53 are hallmarks of cancer. p53 coordinates the response to gamma irradiation (gamma-IR) by either triggering apoptosis or cell cycle arrest. c-Myc activates the p53 apoptotic checkpoint, and thus tumors overexpressing MYC often harbor p53 mutations. Nonetheless, many of these cancers are responsive to therapy, suggesting that Myc may sensitize cells to gamma-IR independent of p53. In mouse embryo fibroblasts (MEFs) and in E micro -myc transgenic B cells in vivo, c-Myc ac...    »
 
Zeitschriftentitel:
Mol Cell Biol 
Jahr:
2003 
Band / Volume:
23 
Heft / Issue:
20 
Seitenangaben Beitrag:
7256-70 
Sprache:
eng 
Print-ISSN:
0270-7306 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik