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Dokumenttyp:
journal article 
Autor(en):
Ruland, J; Duncan, GS; Wakeham, A; Mak, TW 
Titel:
Differential requirement for Malt1 in T and B cell antigen receptor signaling. 
Abstract:
The translocation t(11; 18)(q21; q21) involving MALT1 is the most common chromosomal abnormality in lymphomas of mucosa-associated lymphoid tissue. Although the paracaspase MALT1 can bind to BCL10, the physiological function of MALT1 is unknown. Using mouse models, we show that Malt1 is essential for T cell activation, proliferation, and IL-2 production in response to TCR ligation and strictly required for signal-specific NF-kappaB activation induced by the TCR but not TNF-alpha or IL-1 signalin...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2003 
Band / Volume:
19 
Heft / Issue:
Seitenangaben Beitrag:
749-58 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik