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Dokumenttyp:
journal article 
Autor(en):
Miething, C; Grundler, R; Fend, F; Hoepfl, J; Mugler, C; von Schilling, C; Morris, SW; Peschel, C; Duyster, J 
Titel:
The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model. 
Abstract:
A t(2; 5) (p23; q35) chromosomal translocation can be found in a high percentage of anaplastic large-cell lymphomas (ALCL). This genetic abnormality leads to the expression of the NPM-ALK fusion protein, which encodes a constitutively active tyrosine kinase that plays a causative role in lymphomagenesis. Employing a modified infection/transplantation protocol utilizing an MSCV-based vector, we were able to reproducibly induce two phenotypically different lymphoma-like diseases dependent on the r...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2003 
Band / Volume:
22 
Heft / Issue:
30 
Seitenangaben Beitrag:
4642-7 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie