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Document type:
journal article 
Author(s):
Heid, I; Lubeseder-Martellato, C; Sipos, B; Mazur, PK; Lesina, M; Schmid, RM; Siveke, JT 
Title:
Early requirement of Rac1 in a mouse model of pancreatic cancer. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease without effective chemopreventive or therapeutic approaches. Although the role of oncogenic Kras in initiating development of PDAC is well established, downstream targets of aberrant Ras signaling are poorly understood. Acinar-ductal metaplasia (ADM) appears to be an important prerequisite for development of pancreatic intraepithelial neoplasia (PanIN), a common precursor to PDAC. RAS-related C3 botulinum substrate 1 (Rac1), which contro...    »
 
Journal title abbreviation:
Gastroenterology 
Year:
2011 
Journal volume:
141 
Journal issue:
Pages contribution:
719-30, 730.e1-7 
Language:
eng 
Print-ISSN:
0016-5085 
TUM Institution:
II. Medizinische Klinik und Poliklinik