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Dokumenttyp:
journal article 
Autor(en):
Hackl, D; Loschko, J; Sparwasser, T; Reindl, W; Krug, AB 
Titel:
Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs. 
Abstract:
Exogenous and endogenous RNA ligands of Toll-like receptor (TLR) 7 which are present during viral infection or autoimmune diseases such as systemic lupus erythematosus (SLE) directly activate DCs and B cells and thus support the generation of effector T and B lymphocytes. However, the generation of effective antiviral or autoreactive adaptive immune responses requires blocking of immunosuppression by Tregs. In this study, we show that TLR7 ligands reduce the number of Tregs generated de novo fro...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2011 
Band / Volume:
41 
Heft / Issue:
Seitenangaben Beitrag:
1334-43 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik