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Dokumenttyp:
journal article 
Autor(en):
Steck, N; Hoffmann, M; Sava, IG; Kim, SC; Hahne, H; Tonkonogy, SL; Mair, K; Krueger, D; Pruteanu, M; Shanahan, F; Vogelmann, R; Schemann, M; Kuster, B; Sartor, RB; Haller, D 
Titel:
Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation. 
Abstract:
Matrix metalloproteases (MMPs) mediate pathogenesis of chronic intestinal inflammation. We characterized the role of the gelatinase (GelE), a metalloprotease from Enterococcus faecalis, in the development of colitis in mice.Germ-free, interleukin-10-deficient (IL-10(-/-)) mice were monoassociated with the colitogenic E faecalis strain OG1RF and isogenic, GelE-mutant strains. Barrier function was determined by measuring E-cadherin expression, transepithelial electrical resistance (TER), and trans...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2011 
Band / Volume:
141 
Heft / Issue:
Seitenangaben Beitrag:
959-71 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik