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Dokumenttyp:
journal article 
Autor(en):
Bauer, A; Villunger, A; Labi, V; Fischer, SF; Strasser, A; Wagner, H; Schmid, RM; Häcker, G 
Titel:
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. 
Abstract:
Apoptosis of activated T cells is critical for the termination of immune responses. Here we show that adjuvant-stimulated dendritic cells secrete cytokines that prime activated T cells for survival and analyze the roles of the NF-kappaB regulator Bcl-3 and the proapoptotic Bcl-2 family members Bim and Puma. Bcl-3 overexpression increased survival, and activated bcl-3-/- T cells died abnormally rapidly. Cytokines from adjuvant-stimulated dendritic cells induced Bcl-3, but survival through cytokin...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2006 
Band / Volume:
103 
Heft / Issue:
29 
Seitenangaben Beitrag:
10979-84 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; II. Medizinische Klinik und Poliklinik