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Document type:
journal article 
Author(s):
Hellebrand, E; Mautner, J; Reisbach, G; Nimmerjahn, F; Hallek, M; Mocikat, R; Hammerschmidt, W 
Title:
Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination. 
Abstract:
The efficient gene transfer of immunostimulatory cytokines into autologous tumor cells or the transfer of tumor-associated antigens into professional antigen-presenting cells is a prerequisite for many immunotherapeutic approaches. In particular with B cells, the efficiency of gene uptake is one of the limiting factors in cell-based vaccine strategies, since normal and malignant human B cells are commonly refractory to transducing gene vectors. Due to its natural tropism for human B cells, Epste...    »
 
Journal title abbreviation:
Gene Ther 
Year:
2006 
Journal volume:
13 
Journal issue:
Pages contribution:
150-62 
Language:
eng 
Print-ISSN:
0969-7128 
TUM Institution:
Kinderklinik und Poliklinik