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Document type:
journal article 
Author(s):
Krug, A; French, AR; Barchet, W; Fischer, JA; Dzionek, A; Pingel, JT; Orihuela, MM; Akira, S; Yokoyama, WM; Colonna, M 
Title:
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. 
Abstract:
Natural interferon-producing cells (IPC) respond to viruses by secreting type I interferon (IFN) and interleukin-12 (IL-12). Toll-like receptor (TLR) 9 mediates IPC recognition of some of these viruses in vitro. However, whether TLR9-induced activation of IPC is necessary for an effective antiviral response in vivo is not clear. Here, we demonstrate that IPC and dendritic cells (DC) recognize murine cytomegalovirus (MCMV) through TLR9. TLR9-mediated cytokine secretion promotes viral clearance by...    »
 
Journal title abbreviation:
Immunity 
Year:
2004 
Journal volume:
21 
Journal issue:
Pages contribution:
107-19 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
II. Medizinische Klinik und Poliklinik