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Document type:
journal article 
Author(s):
Krug, A; Luker, GD; Barchet, W; Leib, DA; Akira, S; Colonna, M 
Title:
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. 
Abstract:
Natural interferon-producing cells (IPCs) specialize in the production of high levels of type 1 interferons (IFNs) in response to encapsulated DNA and RNA viruses. Here we demonstrate that the secretion of type 1 IFN in response to herpes simplex virus type 1 (HSV-1) in vitro is mediated by the toll-like receptor 9 (TLR9)/MyD88 pathway. Moreover, IPCs produce interleukin-12 (IL-12) in response to HSV-1 in vitro, which is also dependent on TLR9/ MyD88 signaling. Remarkably, though TLR9/MyD88-defi...    »
 
Journal title abbreviation:
Blood 
Year:
2004 
Journal volume:
103 
Journal issue:
Pages contribution:
1433-7 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
II. Medizinische Klinik und Poliklinik