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Dokumenttyp:
journal article 
Autor(en):
Munzert, G; Kirchner, D; Ottmann, O; Bergmann, L; Schmid, RM 
Titel:
Constitutive NF-kappab/Rel activation in philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). 
Abstract:
The Bcr-Abl translocation t(9; 22)(q34; q11 ) defines a subgroup of ALL patients with a dismal prognosis despite the introduction of intensified induction and consolidation regimen. Although Bcr-Abl induced NF-kappaB/Rel activation has previously been shown, the role of NF-kappaB/Rel in Ph+ leukemia is unclear. Using DNA binding assays, we demonstrate constitutive NF-kappaB/Rel activity in nuclear extracts from Ph+ ALL blasts, whereas Ph- primary blast cells and B-precursor cell lines lack NF-ka...    »
 
Zeitschriftentitel:
Leuk Lymphoma 
Jahr:
2004 
Band / Volume:
45 
Heft / Issue:
Seitenangaben Beitrag:
1181-4 
Sprache:
eng 
Print-ISSN:
1042-8194 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik