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Dokumenttyp:
journal article 
Autor(en):
Schulte, D; Küppers, V; Dartsch, N; Broermann, A; Li, H; Zarbock, A; Kamenyeva, O; Kiefer, F; Khandoga, A; Massberg, S; Vestweber, D 
Titel:
Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. 
Abstract:
To determine whether leukocytes need to open endothelial cell contacts during extravasation, we decided to generate mice with strongly stabilized endothelial junctions. To this end, we replaced VE-cadherin genetically by a VE-cadherin-?-catenin fusion construct. Such mice were completely resistant to the induction of vascular leaks by VEGF or histamine. Neutrophil or lymphocyte recruitment into inflamed cremaster, lung and skin were strongly inhibited in these mice, documenting the importance of...    »
 
Zeitschriftentitel:
EMBO J 
Jahr:
2011 
Band / Volume:
30 
Heft / Issue:
20 
Seitenangaben Beitrag:
4157-70 
Sprache:
eng 
Print-ISSN:
0261-4189 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik