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Document type:
journal article 
Author(s):
Schmidt, R; Redecke, V; Breitfeld, Y; Wantia, N; Miethke, T; Massberg, S; Fischel, S; Neumann, FJ; Schömig, A; May, AE 
Title:
EMMPRIN (CD 147) is a central activator of extracellular matrix degradation by Chlamydia pneumoniae-infected monocytes. Implications for plaque rupture. 
Abstract:
Chlamydia (C.) pneumoniae are thought to infect monocytes and use them as vectors into the vessel wall, where they may accelerate atherosclerosis. We investigated the effects of C. pneumoniae on monocytic matrix metalloproteinase (MMP) activation with focus on the role of the extracellular matrix metalloproteinase inducer EMMPRIN. Human monocytes or monocytic MonoMac6 cells were infected with C. pneumoniae. Infection enhanced mRNA- and surface expression of EMMPRIN and Membrane-type-1 Matrix Met...    »
 
Journal title abbreviation:
Thromb Haemost 
Year:
2006 
Journal volume:
95 
Journal issue:
Pages contribution:
151-8 
Language:
eng 
Print-ISSN:
0340-6245 
TUM Institution:
I. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene