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Document type:
journal article 
Author(s):
Bölck, B; Münch, G; Mackenstein, P; Hellmich, M; Hirsch, I; Reuter, H; Hattebuhr, N; Weig, HJ; Ungerer, M; Brixius, K; Schwinger, RH 
Title:
Na+/Ca2+ exchanger overexpression impairs frequency- and ouabain-dependent cell shortening in adult rat cardiomyocytes. 
Abstract:
The Na(+)/Ca(2+) exchanger (NCX) may influence cardiac function depending on its predominant mode of action, forward mode or reverse mode, during the contraction-relaxation cycle. The intracellular Na(+) concentration ([Na(+)](i)) and the duration of the action potential as well as the level of NCX protein expression regulate the mode of action of NCX. [Na(+)](i) and NCX expression have been reported to be increased in human heart failure. Nevertheless, the consequences of altered NCX expression...    »
 
Journal title abbreviation:
Am J Physiol Heart Circ Physiol 
Year:
2004 
Journal volume:
287 
Journal issue:
Pages contribution:
H1435-45 
Language:
eng 
Print-ISSN:
0363-6135 
TUM Institution:
I. Medizinische Klinik und Poliklinik