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Dokumenttyp:
journal article 
Autor(en):
Massberg, S; Konrad, I; Bültmann, A; Schulz, C; Münch, G; Peluso, M; Lorenz, M; Schneider, S; Besta, F; Müller, I; Hu, B; Langer, H; Kremmer, E; Rudelius, M; Heinzmann, U; Ungerer, M; Gawaz, M 
Titel:
Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo. 
Abstract:
Platelet-collagen interactions play a fundamental role in the process of arterial thrombosis. The major platelet collagen receptor is the glycoprotein VI (GPVI). Here, we determined the effects of a soluble dimeric form of GPVI on platelet adhesion in vitro and in vivo. We fused the extracellular domain of GPVI with the human immunoglobulin Fc domain. The soluble dimeric form of GPVI (GPVI-Fc) specifically bound to immobilized collagen. Binding of GPVI-Fc to collagen was inhibited competitively...    »
 
Zeitschriftentitel:
FASEB J 
Jahr:
2004 
Band / Volume:
18 
Heft / Issue:
Seitenangaben Beitrag:
397-9 
Sprache:
eng 
Print-ISSN:
0892-6638 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie