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Dokumenttyp:
journal article 
Autor(en):
Moers, A; Nieswandt, B; Massberg, S; Wettschureck, N; Grüner, S; Konrad, I; Schulte, V; Aktas, B; Gratacap, MP; Simon, MI; Gawaz, M; Offermanns, S 
Titel:
G13 is an essential mediator of platelet activation in hemostasis and thrombosis. 
Abstract:
Platelet activation at sites of vascular injury is essential for primary hemostasis, but also underlies arterial thrombosis leading to myocardial infarction or stroke. Platelet activators such as adenosine diphosphate, thrombin or thromboxane A(2) (TXA(2)) activate receptors that are coupled to heterotrimeric G proteins. Activation of platelets through these receptors involves signaling through G(q), G(i) and G(z) (refs. 4-6). However, the role and relative importance of G(12) and G(13), which a...    »
 
Zeitschriftentitel:
Nat Med 
Jahr:
2003 
Band / Volume:
Heft / Issue:
11 
Seitenangaben Beitrag:
1418-22 
Sprache:
eng 
Print-ISSN:
1078-8956 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik