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Document type:
journal article 
Author(s):
Wessely, R; Hengst, L; Jaschke, B; Wegener, F; Richter, T; Lupetti, R; Paschalidis, M; Schömig, A; Brandl, R; Neumann, FJ 
Title:
A central role of interferon regulatory factor-1 for the limitation of neointimal hyperplasia. 
Abstract:
Neointima formation, the leading cause of restenosis after catheter angioplasty, is a paradigm for vascular proliferative responses. Neointima formation is self-limiting after a variable degree of tissue growth, causing significant renarrowing in a substantial number of patients. To investigate the mechanisms that limit neointima formation we studied the role of the transcription factor IRF-1, which is a regulator of interferons and a tumor suppressor. We demonstrate that IRF-1 is highly regulat...    »
 
Journal title abbreviation:
Hum Mol Genet 
Year:
2003 
Journal volume:
12 
Journal issue:
Pages contribution:
177-87 
Language:
eng 
Print-ISSN:
0964-6906 
TUM Institution:
I. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie