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Dokumenttyp:
journal article 
Autor(en):
Braun, RJ; Zischka, H; Madeo, F; Eisenberg, T; Wissing, S; Büttner, S; Engelhardt, SM; Büringer, D; Ueffing, M 
Titel:
Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast. 
Abstract:
Mutation in CDC48 (cdc48(S565G)), a gene essential in the endo-plasmic reticulum (ER)-associated protein degradation (ERAD) pathway, led to the discovery of apoptosis as a mechanism of cell death in the unicellular organism Saccharomyces cerevisiae. Elucidating Cdc48p-mediated apoptosis in yeast is of particular interest, because Cdc48p is the highly conserved yeast orthologue of human valosin-containing protein (VCP), a pathological effector for polyglutamine disorders and myopathies. Here we s...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2006 
Band / Volume:
281 
Heft / Issue:
35 
Seitenangaben Beitrag:
25757-67 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r Humangenetik