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Dokumenttyp:
journal article 
Autor(en):
Gloeckner, CJ; Kinkl, N; Schumacher, A; Braun, RJ; O'Neill, E; Meitinger, T; Kolch, W; Prokisch, H; Ueffing, M 
Titel:
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. 
Abstract:
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been recently identified in families with autosomal dominant late-onset Parkinson disease (PD). The LRRK2 protein consists of multiple domains and belongs to the Roco family, a novel group of the Ras/GTPase superfamily. Besides the GTPase (Roc) domain, it contains a predicted kinase domain, with homology to MAP kinase kinase kinases. Using cell fractionation and immunofluorescence microscopy, we show that LRRK2 is localized in the c...    »
 
Zeitschriftentitel:
Hum Mol Genet 
Jahr:
2006 
Band / Volume:
15 
Heft / Issue:
Seitenangaben Beitrag:
223-32 
Sprache:
eng 
Print-ISSN:
0964-6906 
TUM Einrichtung:
r Humangenetik