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Dokumenttyp:
journal article 
Autor(en):
Binder, EB; Salyakina, D; Lichtner, P; Wochnik, GM; Ising, M; Pütz, B; Papiol, S; Seaman, S; Lucae, S; Kohli, MA; Nickel, T; Künzel, HE; Fuchs, B; Majer, M; Pfennig, A; Kern, N; Brunner, J; Modell, S; Baghai, T; Deiml, T; Zill, P; Bondy, B; Rupprecht, R; Messer, T; Köhnlein, O; Dabitz, H; Brückl, T; Müller, N; Pfister, H; Lieb, R; Mueller, JC; Lõhmussaar, E; Strom, TM; Bettecken, T; Meitinger, T; Uhr, M; Rein, T; Holsboer, F; Muller-Myhsok, B 
Titel:
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. 
Abstract:
The stress hormone-regulating hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality as well as the treatment of depression. To investigate a possible association between genes regulating the HPA axis and response to antidepressants and susceptibility for depression, we genotyped single-nucleotide polymorphisms in eight of these genes in depressed individuals and matched controls. We found significant associations of response to antidepressants and the recurrence of depre...    »
 
Zeitschriftentitel:
Nat Genet 
Jahr:
2004 
Band / Volume:
36 
Heft / Issue:
12 
Seitenangaben Beitrag:
1319-25 
Sprache:
eng 
Print-ISSN:
1061-4036 
TUM Einrichtung:
r Humangenetik