User: Guest  Login
Document type:
journal article 
Author(s):
Schmitt, M; Sturmheit, AS; Welk, A; Schnelldorfer, C; Harbeck, N 
Title:
Procedures for the quantitative protein determination of urokinase and its inhibitor, PAI-1, in human breast cancer tissue extracts by ELISA. 
Abstract:
The determination of the protein content of urokinase-type plasminogen activator (uPA) and its inhibitor, PAI-1, in breast cancer tissue extracts is used clinically to identify patients at risk to experience disease recurrence (metastasis) or early death. The serine protease uPA, in concert with its inhibitor PAI-1, promotes tumor cell adhesion, migration, and proliferation, as well as extracellular matrix degradation and, thus, facilitates tumor cell invasion and metastasis. The various technic...    »
 
Journal title abbreviation:
Methods Mol Med 
Year:
2006 
Journal volume:
120 
Pages contribution:
245-65 
Language:
eng 
Print-ISSN:
1543-1894 
TUM Institution:
Frauenklinik und Poliklinik