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Dokumenttyp:
journal article 
Autor(en):
Wilkening, S; Bermejo, JL; Burwinkel, B; Klaes, R; Bartram, CR; Meindl, A; Bugert, P; Schmutzler, RK; Wappenschmidt, B; Untch, M; Hemminki, K; Försti, A 
Titel:
The single nucleotide polymorphism IVS1+309 in mouse double minute 2 does not affect risk of familial breast cancer. 
Abstract:
The mouse double minute 2 (MDM2) oncoprotein promotes cell survival and cell cycle progression by inhibiting the p53 tumor suppressor protein. Further, MDM2 overexpression can inhibit DNA double-strand break repair in a p53-independent manner. Recently, it was shown that a single nucleotide polymorphism (SNP) in the MDM2 promoter was associated with an accelerated tumor formation in individuals with a p53 mutation. The present case-control study investigated the association of this SNP (IVS1+309...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2006 
Band / Volume:
66 
Heft / Issue:
Seitenangaben Beitrag:
646-8 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
Frauenklinik und Poliklinik