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Document type:
journal article 
Author(s):
Boyd, DD; Wang, H; Avila, H; Parikh, NU; Kessler, H; Magdolen, V; Gallick, GE 
Title:
Combination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness. 
Abstract:
PURPOSE: The urokinase-type plasminogen activator receptor (u-PAR) contributes to colon cancer invasion and metastases. We have shown previously that u-PAR expression in colon cancer is driven by the Src tyrosine kinase. In the current study, we determined the ability of PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), a Src kinase inhibitor, to reduce u-PAR expression and colon cancer invasion. EXPERIMENTAL DESIGN: Western blotting, Northern blotting, and u-PAR promoter-re...    »
 
Journal title abbreviation:
Clin Cancer Res 
Year:
2004 
Journal volume:
10 
Journal issue:
Pages contribution:
1545-55 
Language:
eng 
Print-ISSN:
1078-0432 
TUM Institution:
Frauenklinik und Poliklinik