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Document type:
journal article 
Author(s):
Gross, E; Ullrich, T; Seck, K; Mueller, V; de Wit, M; von Schilling, C; Meindl, A; Schmitt, M; Kiechle, M 
Title:
Detailed analysis of five mutations in dihydropyrimidine dehydrogenase detected in cancer patients with 5-fluorouracil-related side effects. 
Abstract:
Complete or partial loss of dihydropyrimidine dehydrogenase (DPD or DYPD) function has been described in cancer patients experiencing severe side effects upon administration of the fluoropyrimidine anticancer drug 5-fluorouracil (5-FU). To investigate a genetic predisposition for 5-FU intolerance due to inherited DPD defects, we established a mutation detection assay based on denaturing HPLC. Analyzing four individuals with symptoms of 5-FU-related toxicity, we detected six distinct sequence var...    »
 
Journal title abbreviation:
Hum Mutat 
Year:
2003 
Journal volume:
22 
Journal issue:
Pages contribution:
498 
Language:
eng 
Print-ISSN:
1059-7794 
TUM Institution:
Frauenklinik und Poliklinik; III. Medizinische Klinik und Poliklinik