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Dokumenttyp:
journal article 
Autor(en):
Kuschel, B; Auranen, A; Gregory, CS; Day, NE; Easton, DF; Ponder, BA; Dunning, AM; Pharoah, PD 
Titel:
Common polymorphisms in checkpoint kinase 2 are not associated with breast cancer risk. 
Abstract:
A substantial proportion of the familial risk of breast cancer may be attributable to genetic variants each contributing a small effect. Polymorphisms in DNA repair genes are good candidates for such low penetrance breast cancer susceptibility alleles. Checkpoint kinase 2 (CHEK2) is a kinase in which the yeast counterpart regulates a cell cycle checkpoint and causes cells to arrest proliferation after DNA damage. A rare, protein truncating mutation in the CHEK2 gene has recently been shown to co...    »
 
Zeitschriftentitel:
Cancer Epidemiol Biomarkers Prev 
Jahr:
2003 
Band / Volume:
12 
Heft / Issue:
Seitenangaben Beitrag:
809-12 
Sprache:
eng 
Print-ISSN:
1055-9965 
TUM Einrichtung:
Frauenklinik und Poliklinik