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Document type:
journal article 
Author(s):
Sela-Passwell, N; Trahtenherts, A; Krüger, A; Sagi, I 
Title:
New opportunities in drug design of metalloproteinase inhibitors: combination between structure-function experimental approaches and systems biology. 
Abstract:
Introduction: MMPs (matrix metalloproteinases) and ADAMs (a disintegrin and metalloproteinases) are endopeptidases central to the degradation and remodeling of the extracellular matrix. These proteases also exhibit regulatory activity in cell signaling pathways and thus tissue homeostasis under normal conditions and in many diseases. Consequently, individual members of the MMP and ADAM protein families were identified as important therapeutic targets. However, designing effective inhibitors in v...    »
 
Journal title abbreviation:
Expert Opin Drug Discov 
Year:
2011 
Journal volume:
Journal issue:
Pages contribution:
527-42 
Language:
eng 
Print-ISSN:
1746-0441 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung