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Dokumenttyp:
journal article 
Autor(en):
Arlt, MJ; Novak-Hofer, I; Gast, D; Gschwend, V; Moldenhauer, G; Grünberg, J; Honer, M; Schubiger, PA; Altevogt, P; Krüger, A 
Titel:
Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. 
Abstract:
The L1 cell adhesion molecule is implicated in the control of proliferation, migration, and invasion of several tumor cell types in vitro. Recently, L1 overexpression was found to correlate with tumor progression of ovarian carcinoma, one of the most common causes of cancer-related deaths in gynecologic malignant diseases. To evaluate L1 as a potential target for ovarian cancer therapy, we investigated the effects of anti-L1 monoclonal antibodies (chCE7 and L1-11A) on proliferation and migration...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2006 
Band / Volume:
66 
Heft / Issue:
Seitenangaben Beitrag:
936-43 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung